Seminars & Events

Fri 20 Jan 2017 from 12:00 to 13:00

Human antibody responses to dengue/Zika virus infections

Prof Gavin Screaton

Audience: Public

Please contact lisbeth.soederberg@ndm.ox.ac.uk to set up a meeting with the speaker.

Mon 23 Jan 2017 from 12:00 to 13:00

Wellcome Trust Centre for Human Genetics, Room A, Headington OX3 7BN

Herpesvirus-based Vaccines for Infectious Disease & Cancer: An uncarved block

Dr Michael Jarvis

Audience: Public

Please contact lisbeth.soederberg@ndm.ox.ac.uk to set up a meeting with the speaker.

Fri 17 Feb 2017 from 09:30 to 10:30

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Improving the efficacy of cancer immunotherapy

Prof. Benoit van den Eynde

Audience: Public

Organisers: Lisbeth Soederberg

Mon 27 Feb 2017 from 12:00 to 13:00

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Continuing to pursue Edward Jenner’s revenge: Sterilizing vaccines in chemotherapy for tuberculosis

Prof William R. Jacobs

Audience: Public

Please contact lisbeth.soederberg@ndm.ox.ac.uk to set up a meeting with the speaker.

Mon 13 Mar 2017 from 11:00 to 12:00

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

BCG induced trained immunity through epigenetic and metabolic reprogramming

Prof Reinout van Crevel

The Bacille Calmette–Guerin (BCG), the only vaccine against tuberculosis, remains the most commonly used vaccine worldwide. In addition to its effects on mycobacterial diseases, BCG also exerts beneficial non-specific effects ranging from protection against non-mycobacterial diseases, decreased... Read more

The Bacille Calmette–Guerin (BCG), the only vaccine against tuberculosis, remains the most commonly used vaccine worldwide. In addition to its effects on mycobacterial diseases, BCG also exerts beneficial non-specific effects ranging from protection against non-mycobacterial diseases, decreased incidence of allergic diseases, and treatment of certain malignancies. This is thought to be caused by potentiation of innate immune responses through epigenetic mechanisms, a process termed ‘trained immunity’. The process of trained immunity may also account for BCG-associated resistance to infection with Mycobacterium tuberculosis tuberculosis (also termed ‘early clearance’), and this could have important consequences for our quest for improving tuberculosis vaccination strategies. BCG-induced trained immunity results in an increased in-vitro responsiveness of monocytes and macrophages, with effector functions such as cytokine production and reactive oxygen species release being increased upon secondary stimulation with non-related pathogens. The change in inflammatory profile and the underlying epigenetic changes are dependent on changes in cellular metabolism, and these metabolic changes are also epigenetically mediated, hence showing a complex interaction between immunometabolic pathways and epigenetic modifications in trained immunity.

Audience: Public

Please contact lisbeth.soederberg@ndm.ox.ac.uk to set up a meeting with the speaker.