Seminars & Events

Fri 16 Oct 2015 from 12:00 to 13:00

Richard Doll Building, Lecture Theatre (ring CTSU bell to enter), Old Road Campus OX3 7LF

Fish vaccination: Successes and future needs

Prof Chris Secombes

Audience: Public

Organisers: Lisbeth Soederberg

Mon 19 Oct 2015 from 12:00 to 13:00

NDM Building, NDMRB - Basement Seminar room, Headington OX3 7FZ

Mass Spectrometry Based Immunopeptidomics - From Discoveries to Therapies

Dr Michal Bassani-Sternberg

Audience: Members of the University only

Mon 19 Oct 2015 from 12:00 to 13:00

NDM Building, NDMRB - Basement Seminar room, Headington OX3 7FZ

Mass Spectrometry Based Immunopeptidomics - From Discoveries to Therapies

Dr Michal Bassani-Sternberg

Audience: Members of the University only

Fri 20 Nov 2015 from 15:30 to 16:30

Establishment of robust salivary gland-specific expression in transgenic anopheline mosquito

Shigeto Yoshida

Recent advances in the genetically engineering of Anopheline mosquitoes have raised hopes for their use as new strategies for malaria control and provided a powerful tool to investigate parasite-mosquito interactions. The interruption of the parasite cycle in the mosquito using transgenic... Read more

Recent advances in the genetically engineering of Anopheline mosquitoes have raised hopes for their use as new strategies for malaria control and provided a powerful tool to investigate parasite-mosquito interactions. The interruption of the parasite cycle in the mosquito using transgenic strategies can occur at the midgut level, interfering with ookinete invasion or oocyst differentiation, and at the salivary gland level, blocking invasion of gland cells or the transmission of infective sporozoites from the salivary glands. So far, only the carboxypeptidase and vitellogenine promoters have been used for driving transgenes in mosquitoes for the gut- and fat body- specific expression, respectively. Therefore, research on transmission blockade using transgenic mosquitoes has been limited to the midgut stage of the parasites. In the seminar, Shigeto Yoshida will present the development of transgenic Anopheles stephensi mosquitoes that specifically express Discosoma sp. red fluorescent protein (DsRed) in their salivary glands. Using advanced 3D confocal microscopy, robust expression of DsRed in the distal-lateral lobes of the salivary glands is observed, where the sporozoites invade preferentially, driven by a newly isolated salivary gland-specific promoter in a living mosquito as well as in dissected salivary glands. Furthermore, by using GFP-expressing sporozoites, Shigeto Yoshida will also show the parasites passing through the salivary glands from the outer surface. These results open up the possibility of elucidating the process and molecules involved in the salivary glands-parasites interactions, and may lead to the development of transmission-blocking strategies by using genetically modified mosquitoes that express anti-parasitic genes in a salivary gland-specific manner.

Audience: Members of the University only

Wed 25 Nov 2015 from 12:00 to 13:00

Richard Doll Building, Lecture Theatre (press CTSU bell to enter), Old Road Campus OX3 7LF

Alphavirus, encephalitis and arthralgia

Prof John Fazakerley

Audience: Members of the University only

Organisers: Lisbeth Soederberg

Mon 14 Dec 2015 from 12:00 to 13:00

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Inducing intestinal immunity with live oral vaccines: lessons from poliovirus

Prof Nick Grassly

Audience: Members of the University only

Organisers: Lisbeth Soederberg