Other Seminars

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Wed 1 Jun 2016 from 12:00 to 13:00

SGC Seminars

NDM Building, Basement seminar room, Headington OX3 7FZ

“Imaging proteins at the single molecule level”

Jean-Nicolas Longchamp

Imaging a single protein has been a long-standing aspiration for advancing structural biology and with this various fields in natural science. Here I will show that, sub-nanometer resolved images of individual folded proteins have been obtained for the first time. Electrospray ion beam deposition... Read more

Imaging a single protein has been a long-standing aspiration for advancing structural biology and with this various fields in natural science. Here I will show that, sub-nanometer resolved images of individual folded proteins have been obtained for the first time. Electrospray ion beam deposition for the specific selection and sound deposition of individual proteins onto ultraclean freestanding graphene in an ultra-high vacuum environment and low-energy electron holography for the non-destructive imaging are combined in a novel experimental workflow.

Audience: Public

Organisers: Natsumi Astley

Wed 1 Jun 2016 from 13:00 to 14:00

Oxford Genomic Centre Seminars

Wellcome Trust Centre for Human Genetics, Seminar Rooms A and B, Headington OX3 7BN

Admixed populations, and strategies for nanopore data analysis

David Eccles

David Eccles is a freelance bioinformatician based at the Malaghan Institute for Medical Research in Wellington, New Zealand. He has working on various topics related to human genetics; co-wrote the Trinity De-novo RNA Sequence assembly program while based at the Max Planck Institute in... Read more

David Eccles is a freelance bioinformatician based at the Malaghan Institute for Medical Research in Wellington, New Zealand. He has working on various topics related to human genetics; co-wrote the Trinity De-novo RNA Sequence assembly program while based at the Max Planck Institute in Muenster, Germany; is an active member of the MinION Analysis and Reference Consortium, an international group exploring methods and applications for Oxford Nanopore data; and recently spoke on "Sequencing that stimulates the sensors" at a TEDxWellington event. David will be available to meet with interested researchers during the day. -- Estimation of Genomic Ancestry in Admixed Populations - David Eccles, Geoff Chambers, Rod Lea -- The native Maori settlement of New Zealand about 600 years ago represents an end-point of a long journey of island-hopping voyages across vast stretches of open sea -- the last of the great human migrations. Nearly 250 years ago, European settlers discovered this remote island country in the South Pacific, and thus began the mixing of two cultures that were literally oceans apart. The Maori population of today presents an exciting opportunity to study recent ancestral population admixture. A bootstrap sub-sampling method was utilised to generate a set of group-specific markers for the investigation of admixture within an iwi (Maori tribe) from Hawkes Bay, New Zealand. A validated set of 10 markers was constructed that estimates individual ancestral fraction with high accuracy (median = 98%, IQR = 95-99). These markers were used to determine the variation of Maori-European ancestral fraction within this tribe, together with an estimate of the amount of European ancestry in the population (28.7%). The generation of a panel of validated group-specific markers is possible even when using a low-density marker set and small sample group sizes. This method is likely applicable to other genome-wide studies, and provides one way in which false positive associations could be quickly excluded from candidate marker sets. -- The MinION: New Data; New Analyses - David Eccles -- The Oxford Nanopore MinION is unique among DNA sequencing technology, in that it is the only technology that doesn't require synthesis in order to derive a DNA sequence. Instead, sensors detects subtle changes in the electrical properties of bases, observing single strands of DNA as they pass through a nanopore. The novelty of signal-level data produced by the MinION presents new opportunities for data display and analysis. Over the course of the last two years, a number of different methods were developed to represent both signal-level and base-called MinION data. Three of these methods will be demonstrated: * A colour-based visual representation of pairwise alignment * Aligning raw sensor data to sequenced bases * Turning signal squiggles into sound The disruptive nature of this new sequencing technology means that there is plenty of scope for new research and analysis. It is hoped that by demonstrating a few things that can be done with the technology, others can be inspired to discover other novel uses for the device.

Audience: Members of the University only

Organisers: Camilla Ip

Thu 2 Jun 2016 from 10:30 to 11:30

Nuffield Department of Primary Care Health Sciences - Department research seminars

St Luke's Chapel, Woodstock Road OX2 6GG

"Switching Costs in Medicare Part D Program with Forward Looking Consumers”

Dr Levonyan Vardges

Audience: Members of the University only

Organisers: Catia Nicodemo

Thu 2 Jun 2016 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, TDI, Basement seminar room. (Note: not the ORCRB), Headington OX3 7FZ

Live imaging the earliest events during tumour initiation

Dr Yi Feng

Yi Feng’s group uses a combination of live imaging and genetic analysis in zebrafish larvae to study the earliest events of tumour initiation and progression, in vivo and in real time. They focus on the interactions between transformed cells, normal host tissue and infiltrating innate immune... Read more

Yi Feng’s group uses a combination of live imaging and genetic analysis in zebrafish larvae to study the earliest events of tumour initiation and progression, in vivo and in real time. They focus on the interactions between transformed cells, normal host tissue and infiltrating innate immune cells. Their research is aimed at understanding the underlying cellular and molecular mechanisms regulating tumour initiation, and the contribution of inflammation to tumour promotion with the aim of identifying fundamental mechanisms, which will underpin novel therapeutic approaches.

Audience: Members of the University only

Organisers: Mary Muers

Thu 2 Jun 2016 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Haematology / Cardiology

Haematology: "Novel treatments for ALL", Dr Andy Peniket -- Cardiology: “Phaeochromocytoma and catecholamine cardiotoxicity”, Dr Alexandre Mathy and Dr Vanessa Ferreira -- Chair: Prof Hugh Watkins

Haematology: "Novel treatments for ALL", Dr Andy Peniket -- Cardiology: “Phaeochromocytoma and catecholamine cardiotoxicity”, Dr Alexandre Mathy and Dr Vanessa Ferreira -- Chair: Prof Hugh Watkins

Audience: Public

Audience: Members of the University and NHS clinical staff.

Thu 2 Jun 2016 from 16:30 to 17:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, Seminar Room 2b, Post Grad, Headington OX3 9DU

Fri 3 Jun 2016 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

'Pre-hospital emergency medicine—recent developments and top tips for the first on scene’

Lt Col Ross Moy

Lt Col Moy is a Consultant in Emergency Medicine in the British Army, and The John Radcliffe Hospital. He also works with Thames Valley Air Ambulance as Pre-Hospital Care Physician. He previously served as Regimental Medical Officer to the Queen’s Royal Lancers, and has deployed to Iraq and Afghanistan in both the Emergency Department and Pre-Hospital roles.

Lt Col Moy is a Consultant in Emergency Medicine in the British Army, and The John Radcliffe Hospital. He also works with Thames Valley Air Ambulance as Pre-Hospital Care Physician. He previously served as Regimental Medical Officer to the Queen’s Royal Lancers, and has deployed to Iraq and Afghanistan in both the Emergency Department and Pre-Hospital roles.

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 3 Jun 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

B Cell autophagy and lupus

Alexander Clarke

Audience: Members of the University only

Organisers: Anne Farmer

Fri 3 Jun 2016 from 13:00 to 14:00

Department of Oncology

Old Road Campus Research Building, 71A, B and C, Headington OX3 7DQ

Control of cancer cell growth and drug sensitivity by EGFR palmitoylation

Dr Eric Witze

Audience: Members of the University only

Organisers: Eric O'Neill

Fri 3 Jun 2016 from 13:00 to 14:00

Tropical Medicine Global Health Seminars

NDM Building, Basement Seminar Room, Catering provided so please arrive promptly - First come, first served, Headington OX3 7FZ

A round-trip journey developing evidence-based guidelines for Kenyan children with indrawing pneumonia

Dr. Ambrose Agweyu

More about the topic: The presentation will begin with a comparison of the World Health Organization (WHO) recommendations for empirical treatment of childhood pneumonia pre-2013 and post-2013, along with the rationale supporting the change from injectable to oral antibiotics for indrawing... Read more

More about the topic: The presentation will begin with a comparison of the World Health Organization (WHO) recommendations for empirical treatment of childhood pneumonia pre-2013 and post-2013, along with the rationale supporting the change from injectable to oral antibiotics for indrawing pneumonia. Ambrose will then describe the initial rejection of the proposed new recommendation by national expert panel in Kenya illustrating the position of policy makers in many other regions of sub-Saharan Africa. A clinical trial conducted to address the gaps in evidence that emerged from concerns raised by the Kenyan policy makers is then presented. The talk ends by revisiting the recommendation initially proposed to Kenyan guideline panelist alongside the new local evidence. More about the speaker: Ambrose is a Kenyan paediatrician with Masters training in epidemiology, based at the KEMRI-Wellcome Trust Research Programme in Nairobi. Working closely with the Kenyan Ministry of Health in 2009, his early research involved conducting systematic reviews for a national exercise to adapt the World Health Organization paediatric clinical practice guidelines using the GRADE methodology. Following this, Ambrose was invited to support similar exercises in Uganda and Rwanda. More recently, he was the principal investigator on a large pragmatic clinical trial comparing antibiotic treatments for childhood pneumonia. The findings of this study contributed towards a recent major revision in the Kenyan guidelines, and are likely to eventually influence practice in the region. As he approaches the end of his PhD training, he is currently considering future areas of work that build on his interest in conducting pragmatic trials for interventions to improve the care and outcomes of hospitalized children in sub-Saharan Africa.

Audience: Members of the University only

Organisers: Francois Van Loggerenberg

Mon 6 Jun 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Regulation of lymphocyte development by RNA binding proteins

Martin Turner

Audience: Members of the University only

Organisers: Linda Roberts

Mon 6 Jun 2016 from 14:00 to 15:00

Jenner Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Harnessing the immune system: antibodies as therapeutics against viral and bacterial infections

Dr Man-Wah Tan

Audience: Members of the University only

Organisers: Lisbeth Soederberg

To request a meeting with the speaker please contact: lisbeth.soederberg@ndm.ox.ac.uk

Tue 7 Jun 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Insights into inherited susceptibility to B-cell malignancies

Professor Richard Houlston

Audience: Members of the University only

Organisers: Liz Rose

Tue 7 Jun 2016 from 13:00 to 14:00

Richard Doll Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Tue 7 Jun 2016 from 13:00 to 14:00

Oxford Genomic Centre Seminars

Wellcome Trust Centre for Human Genetics, Seminar room A and B, Headington OX3 7BN

Better understanding of Disease and Health Using Protein Biomarkers

Dr Xavier Tait, Professor Manuel Mayr

Introduction: A Precision Proteomics Solution for Targeted Human Protein Biomarker Discovery with Proseek Multiplex. Dr Xavier Tait, Olink Proteomics, UK Main presentation: "A Multi-omnics Approach to Explore Biomarkers of Disease" Professor Manuel Mayr, King's College London Technologies for... Read more

Introduction: A Precision Proteomics Solution for Targeted Human Protein Biomarker Discovery with Proseek Multiplex. Dr Xavier Tait, Olink Proteomics, UK Main presentation: "A Multi-omnics Approach to Explore Biomarkers of Disease" Professor Manuel Mayr, King's College London Technologies for large-scale analysis of proteins are increasingly driving the discovery of new biomarkers that are important in disease processes. Olink Proteomics provides Proseek [R] Multiplex, an innovative and high-multiplex immunoassay solution for simultaneous detection of 92 proteins across 96 samples, using just one microliter of sample and compatible with a wide range of human body fluids. Our goal is to accelerate the search for new multivariate protein expression patterns that could serve as biomarkers to improve prediction and prognosis of diseases, as well as discovery of new drug targets. This can be used on the Fluidigm Biomark HD platforms already part of the portfolio of technologies held by the Oxford Genomics Centre

Audience: Public

Organisers: Dr Christine Blancher

Wed 8 Jun 2016 from 10:30 to 11:30

Nuffield Department of Primary Care Health Sciences - Department research seminars

St Luke's Chapel, Woodstock Road OX2 6GG

Obamacare: How does the insurance market work?

Professor Richard Scheffler

Audience: Members of the University only

Organisers: Catia Nicodemo

Wed 8 Jun 2016 from 12:00 to 13:00

Strubi seminars

Wellcome Trust Centre for Human Genetics, Meeting Room A/B, Headington OX3 7BN

Proteus mirabilis copper resistance protein is a shape-shifting redox foldase

Prof Jennifer Martin

In the hunt for targets for a new class of antibacterials to overcome antibiotic resistance, we stumbled across an extraordinary shape-shifting protein. Proteus mirabilis ScsC - which supports bacterial swarming motility under copper stress - is a disulfide isomerase. Previously characterised... Read more

In the hunt for targets for a new class of antibacterials to overcome antibiotic resistance, we stumbled across an extraordinary shape-shifting protein. Proteus mirabilis ScsC - which supports bacterial swarming motility under copper stress - is a disulfide isomerase. Previously characterised bacterial disulfide isomerases are dimeric quality control agents that shuffle incorrect disulfide bonds in misfolded proteins. Unexpectedly, we show that PmScsC is not a dimer - but a trimer. We solved three crystal structures of PmScsC, revealing that it undergoes extraordinary twisting and extending motions. These motions - that underpin the function of PmScsC - are a consequence of a short, highly flexible shape-shifting motif resulting in major changes to the overall dimensions of the proteins, almost doubling its length in one dimension.

Audience: Members of the University only

Organisers: Agata Krupa

Wed 8 Jun 2016 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

From Broadly Neutralising Antibodies to a New Mechanism of Diversification

Professor Antonio Lanzavecchia

Audience: Members of the University only

Organisers: Anne Farmer

Wed 8 Jun 2016 from 16:00 to 17:00

Oxford Genomic Centre Seminars

MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS

Single Cell Multi-omics: Exploiting C1 Versatility for 96 or 800 Cells

Ken Livak

Ken is a Fluidigm Senior Scientific Fellow situated at the Broad Institute. He has been developing single cell methods for ten years with a particular emphasis on increasing the number and types of analytes detected. The presentation will include discussion of single cell protocols for protein... Read more

Ken is a Fluidigm Senior Scientific Fellow situated at the Broad Institute. He has been developing single cell methods for ten years with a particular emphasis on increasing the number and types of analytes detected. The presentation will include discussion of single cell protocols for protein and RNA quantification in the same single cell, DR-Seq, RRBS, Cel-Seq2, and ATAC-seq. Ken will be available to meet with interested researchers during the day.

Audience: Members of the University only

Organisers: Rory Bowden

Thu 9 Jun 2016 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

* CANCELLED * Single-cell omics with microfluidics and mass cytometry

Dr Dave Ruff

Dave Ruff is Principal Scientist at Fluidigm Corporation (San Francisco) and a visiting Senior Research Fellow at the WTCHG here at the University of Oxford. Dave collaborates with the global scientific community to innovate and advance biomolecular detection and quantification tools for... Read more

Dave Ruff is Principal Scientist at Fluidigm Corporation (San Francisco) and a visiting Senior Research Fellow at the WTCHG here at the University of Oxford. Dave collaborates with the global scientific community to innovate and advance biomolecular detection and quantification tools for single-cell and systems biology research. Before joining Fluidigm in early 2013, Dave spent 17 years innovating qPCR and next-generation sequencing (NGS) technologies at Applied Biosystems/Life Technologies. He has been a lead investigator in the development of single-cell analysis, qPCR assays and chemistry, multiplex preamplification, protein quantification, NGS library preparation and sample-to-answer workflows, and nucleic acid sample-prep processes. Dave holds a degree in biochemistry from the University of California, Riverside, and a PhD in molecular biology from the California Institute of Technology.

Audience: Members of the University only

Organisers: Gintare Kolesnikovaite

Due to unforeseen circumstances the seminar is now cancelled and will be rescheduled at a later date. Apologies for any inconvenience caused.

Thu 9 Jun 2016 from 12:30 to 13:30

Tropical Medicine Global Health Seminars

NDM Building, Basement Seminar Room, Catering provided so please arrive promptly - First come, first served, Headington OX3 7FZ

Pay for performance in health systems: Theory, evidence and case studies

Professor Richard Scheffler

Professor Scheffler will provide a conceptual framework that shows how pay for performance works in health. Then he will present the results of a survey on pay for performance in Organization for Economic Cooperation and Development (OECD) countries. Finally, Dr. Scheffler will discuss the results... Read more

Professor Scheffler will provide a conceptual framework that shows how pay for performance works in health. Then he will present the results of a survey on pay for performance in Organization for Economic Cooperation and Development (OECD) countries. Finally, Dr. Scheffler will discuss the results of selected case studies on P4P and end with a discussion of what the benefits and limitations are for using pay for performance in health.

Audience: Members of the University only

Organisers: Dr Francois van Loggerenberg

Thu 9 Jun 2016 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Medical Director's Office / Stroke Medicine

Dr Clare Dollery, Dr Phil Mathieson, Dr Helen Higham

Medical Director's Office: "Understanding awareness and its medical consequences", Dr Clare Dollery and Dr Helen Higham -- Stroke Medicine: "Old syndrome, new complications", Dr Phil Mathieson -- Chair: Prof Chris Conlon

Medical Director's Office: "Understanding awareness and its medical consequences", Dr Clare Dollery and Dr Helen Higham -- Stroke Medicine: "Old syndrome, new complications", Dr Phil Mathieson -- Chair: Prof Chris Conlon

Audience: Public

Audience: Members of the University and NHS clinical staff.

Fri 10 Jun 2016 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

'Non-technical skills for surgeons: a hard time for soft skills'

Professor George Youngson CBE

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 10 Jun 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

MAIT cell agonists: a novel class of adjuvants?

Dr Mariolina Salio

Audience: Members of the University only

Organisers: Anne Farmer

Mon 13 Jun 2016 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, 71A, B and C, Headington OX3 7DQ

Strategies for radiosensitization with gold nanoparticles

Sunil Krishnan

Audience: Members of the University only

Organisers: Eric O'Neill

Mon 13 Jun 2016 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

A role for blood derived mononuclear cells in joint surface defect repair

Dr Frances Henson

Audience: Members of the University only

Organisers: Gintare Kolesnikovaite

Mon 13 Jun 2016 from 14:00 to 15:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Meiosis, recombination, and the origin of a species

Peter Donnelly

Audience: Members of the University only

Organisers: Linda Roberts

Mon 13 Jun 2016 from 14:00 to 15:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

‘Non-coding RNAs in vascular disease detection and therapy’

Lars Maegdefessel, MD PhD

Audience: Members of the University only

Organisers: Gintare Kolesnikovaite

Mon 13 Jun 2016 from 16:30 to 17:30

Dopamine Club

Sherrington Building, Sherrington Library, DPAG, off Parks Road OX1 3PT

"Macroautophagy, alpha-synuclein, and dopamine neurotransmission" and "Dopamine timing and reinforcement. Relevance to dyskinesias in PD"

Ben Hunn, John Reynolds

Ben Hunn (DPAG, Oxford) “Macroautophagy, alpha-synuclein, and dopamine neurotransmission” John Reynolds (University of Otago, New Zealand) “"Dopamine timing and reinforcement. Relevance to dyskinesias in PD?"” Chair: Richard Wade-Martins (DPAG) Join us for our meeting this term to... Read more

Ben Hunn (DPAG, Oxford) “Macroautophagy, alpha-synuclein, and dopamine neurotransmission” John Reynolds (University of Otago, New Zealand) “"Dopamine timing and reinforcement. Relevance to dyskinesias in PD?"” Chair: Richard Wade-Martins (DPAG) Join us for our meeting this term to explore dopamine function and its dysfunction in striatal circuits and in relation to aspects of Parkinson’s disease, with two talks chaired by Richard Wade-Martins. We are delighted to welcome Dr John Reynolds from NZ as an external speaker. John will resident be in Oxford on sabbatical for the next few months so do come along to meet him. Doors open 4pm for drinks/nibbles, and talks begin 4:30pm. Please come along and contribute your thoughts to lively discussions! Dopamine Club brings researchers together from across the University to exchange ideas and perspectives on dopamine in an informal setting. Meetings are once a term and are chaired by different labs on a rotating basis. If there are particular speakers, topics or techniques you would like discussed, or you would like to chair a meeting or be more involved, then please get in touch. Look forward to seeing you on June 13th. Steph and Richard

Audience: Members of the University only

Organisers: Dr Stephanie Cragg

Tue 14 Jun 2016 from 10:30 to 11:30

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

NPEU Seminar: Public Engagement with Research: A Brief Introduction

Dr Michaela Livingston-Banks

Audience: Public

Organisers: Dr Manisha Nair

Tue 14 Jun 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Novel mechanisms and therapies in acute myeloid leukaemia

Professor Tim Somervaille

Audience: Members of the University only

Organisers: Liz Rose

Tue 14 Jun 2016 from 13:00 to 14:00

Richard Doll Seminars

Tue 14 Jun 2016 from 14:00 to 15:00

WTCHG Spotlight Series

Wellcome Trust Centre for Human Genetics, Rooms A & B, Headington OX3 7BN

Spotlight on Oxygen

Professor Chris Pugh, Dr Emma Hodson, Professor David Mole

The second seminar in the WTCHG's Spotlight Seminar series will be chaired by Professor Chris Pugh, with talks from Dr Emma Hodson and Professor David Mole.

The second seminar in the WTCHG's Spotlight Seminar series will be chaired by Professor Chris Pugh, with talks from Dr Emma Hodson and Professor David Mole.

Audience: Members of the University only

Tue 14 Jun 2016 from 17:00 to 18:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

NDPH Inaugural Lecture: The contribution of physical activity to mortality

Booking Required

Audience: Members of the University only

Organisers: Graham Bagley

Confirm attendance by Thursday 9 June

Wed 15 Jun 2016 from 12:00 to 13:00

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, Level 5 Seminar Room, Headington OX3 9DU

Human Focus Group Meeting- Powrie Lab

Dr Nate West

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Wed 15 Jun 2016 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Using super-resolution microscopy to watch immune cells kill

Prof Dan Davis

Audience: Members of the University only

Organisers: Anne Farmer

Wed 15 Jun 2016 from 15:15 to 16:15

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

A systems biology approach to identifying drug targets and predicting therapeutic outcomes in myelodysplasia and acute myeloid leukaemia

Ass. Professor John Pimanda

Dr Pimanda will present results from a body of work using functional genomics to develop tools to predict drug response in Myelodysplasia (MDS), identify alternate treatment options for patients who fail current treatment and characterise treatment related changes to the sub-clonal architecture and... Read more

Dr Pimanda will present results from a body of work using functional genomics to develop tools to predict drug response in Myelodysplasia (MDS), identify alternate treatment options for patients who fail current treatment and characterise treatment related changes to the sub-clonal architecture and function of dysplastic haematopoietic stem/progenitor cells (HSPCs). He will also present an integrative analysis of long intergenic non-coding RNA (lincRNAs) expression from 922 acute myeloid leukemia patients. These analyses show that leukemic and normal hematopoietic cell subsets express distinct lincRNAs and that gene signatures composed of as few as three lincRNA genes are independent predictors of clinical outcome across multiple patient cohorts.

Audience: Members of the University only

Organisers: Liz Rose

Wed 15 Jun 2016 from 16:00 to 17:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Tumour-associated macrophages

Toby Lawrence PhD

Audience: Members of the University only

Organisers: Gintare Kolesnikovaite

Thu 16 Jun 2016 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Gastroenterology / Palliative Care

Dr Victoria Bradley, Dr Kate Williamson, Dr Satish Keshav, Prof Paul Klenerman

Gastroenterology: "Blood and Guts… and Liver?", Dr Kate Williamson, Dr Satish Keshav and Prof Paul Klenerman -- Palliative Care: "How to choose your opiate; a connoisseur's guide", Dr Victoria Bradley -- Chair: Prof Hugh Watkins

Gastroenterology: "Blood and Guts… and Liver?", Dr Kate Williamson, Dr Satish Keshav and Prof Paul Klenerman -- Palliative Care: "How to choose your opiate; a connoisseur's guide", Dr Victoria Bradley -- Chair: Prof Hugh Watkins

Audience: Public

Audience: Members of the University and NHS clinical staff.

Fri 17 Jun 2016 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

'The Development and Effects of Thrombectomy in the Treatment of Acute Stroke'

Professor Gerhard Schroth

Professor Gerhard Schroth is Emeritus Professor of Radiology/Euroradiology at the University of Bern in Switzerland, and Senior Consultant at the Institute of Diagnostic and Interventional Neuroradiology at the University of Bern (Inselspital) and the Neurocentro della Svizzera Italiana, Lugano.

Professor Gerhard Schroth is Emeritus Professor of Radiology/Euroradiology at the University of Bern in Switzerland, and Senior Consultant at the Institute of Diagnostic and Interventional Neuroradiology at the University of Bern (Inselspital) and the Neurocentro della Svizzera Italiana, Lugano.

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 17 Jun 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

An update on investigation of IFITM3-rs12252C and its association with influenza virus infection

Henry Laurenson-Schafer

Audience: Members of the University only

Organisers: Anne Farmer

Fri 17 Jun 2016 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, DPAG Large Lecture Theatre, Sherrington Building, off Parks/South Parks Road, OX1 3PT T: 01865 272500 , off Parks Road OX1 3PT

INT'L GUEST: Professor Kenneith Fischbeck MD, NINDS, NIH Bethesda MD : ‘Spinal and bulbar muscular atrophy’

Prof Kenneth Fischbeck MD

Spinal and bulbar muscular atrophy Kenneth Fischbeck, M.D., National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Spinal and bulbar muscular atrophy (SBMA, Kennedy’s disease) is a progressive X-linked neuromuscular disorder with bulbar and... Read more

Spinal and bulbar muscular atrophy Kenneth Fischbeck, M.D., National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Spinal and bulbar muscular atrophy (SBMA, Kennedy’s disease) is a progressive X-linked neuromuscular disorder with bulbar and extremity muscle weakness, atrophy, and fasciculations. Affected males may also show signs of androgen insensitivity. The causative mutation is expansion of a CAG repeat in the androgen receptor gene on the X chromosome. The mutation causes expansion of a polyglutamine tract in the receptor protein, which results in loss of receptor function and makes the protein toxic to motor neurons and muscle. The toxicity of the mutant protein in SBMA is likely related to the mechanism of other polyglutamine expansion diseases; as with the others it is evident in cell culture and animal models and associated with inclusion formation and protein aggregation. The mutant receptor protein has aberrant interactions with other nuclear factors, leading to transcriptional dysregulation and adverse effects on axonal transport, signal transduction, mitochondrial function, and autophagy. Importantly, the toxicity of the mutant protein is ligand-dependent in transgenic flies and mice. Androgen reduction mitigates disease manifestations in mice, but placebo-controlled trials have not yet shown effects on primary outcome measures in patients. Thus there is a need for better therapeutic targets. Other interventions such as Hsp90 inhibition that block the toxic effects of the mutant protein or enhance cellular protective mechanisms have been effective in mice. We and others have found benefits with the synthetic curcumins ASC-J9 and ASC-JM17, which reduce toxic protein levels and activate Nrf1/Nrf2. IGF-1 over-expression and administration are also beneficial in SBMA mice, and a placebo-controlled clinical trial of an IGF-1 agonist is currently underway. Finally, targeting disease gene expression with miRNA and antisense oligonucleotides has been effective in mouse models, and a clinical oligonucleotide trial is planned. SBMA currently has tractable therapeutic targets with preclinical efficacy, biomarkers to confirm target engagement, and established outcome measures to test benefit in patients. Thus the path to safe and effective treatment is clear.

Audience: Members of the University only

Organisers: Sarah Noujaim

INT'L GUEST SPEAKER

Fri 17 Jun 2016 from 13:00 to 14:00

Richard Doll Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Fri 17 Jun 2016 from 13:00 to 14:00

NDM Seminar Series

Wellcome Trust Centre for Human Genetics, Meeting Rooms A&B, Headington OX3 7BN

Mon 20 Jun 2016 from 09:00 to 17:30

Centre for Personalised Medicine Seminars

Ruth Deech Building, Venue accessible for wheelchair users

Big Data, Ethics and the Market

Adrian Walsh, Natalie Banner, Steve Sturdy, Mark Bale, Sir Rory Collins, Gil McVean, Peter Donnelly

The translation of genomic medicine from basic research into medical practice involves partnership of public sector and private companies. Recent empirical research demonstrates that public attitudes towards commercial interests in healthcare are, at best, hesitant. Importantly these attitudes... Read more

The translation of genomic medicine from basic research into medical practice involves partnership of public sector and private companies. Recent empirical research demonstrates that public attitudes towards commercial interests in healthcare are, at best, hesitant. Importantly these attitudes involve significant ethical and conceptual claims and presuppositions about the ethics of markets and the relationship between markets and other areas of value, specifically health and health care. The Centre for Personalised Medicine and the Ethox Centre of the University of Oxford, are hosting a conference that will explore how a publicly funded healthcare system can optimise partnerships with the commercial sector in using data to improve patient outcomes, whilst maintaining its central principles of patient care.

Booking Required

Audience: Public

Organisers: Catherine Lidbetter

Oxford University students can apply for a sponsored place. Please email cpm@well.ox.ac.uk before filling in the online form,

Mon 20 Jun 2016 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Mitochondrial dysfunction and MAVS regulation in lupus: return of the LE cell

Ralph C. Budd, M.D.

Dr. Budd has directed the Immunobiology Program at UVM for the past 20 years, and more recently the Vermont Center for Immunology and Infectious Diseases (VCIID) for the past 9 years. He directed the Cell and Molecular Biology Graduate Program for three years, and has been PI for a T32 Training... Read more

Dr. Budd has directed the Immunobiology Program at UVM for the past 20 years, and more recently the Vermont Center for Immunology and Infectious Diseases (VCIID) for the past 9 years. He directed the Cell and Molecular Biology Graduate Program for three years, and has been PI for a T32 Training Grant for Immunology and Infectious Diseases as well as for a P01 Program Project Grant. He is a former Pew scholar in the Biological Sciences, a member of the Association of American Physicians, and was a 2009 UVM University Scholar. He has served on numerous NIH study sections, and chaired five of them. Dr. Budd has mentored 11 graduate students, 11 postdoctoral fellows, and 11 junior faculty, 5 of whom are now tenured.

Audience: Members of the University only

Organisers: Gintare Kolesnikovaite

Mon 20 Jun 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Title TBC

Martin Pule

Audience: Members of the University only

Organisers: Linda Roberts

Tue 21 Jun 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

The first human immortalised cell line generated from adult erythroid cells

Dr Jan Frayne

Audience: Members of the University only

Organisers: Liz Rose

Tue 21 Jun 2016 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Building, Small Lecture Theatre (note main door closes at 4pm), off Parks Road OX1 3PT

Professor Jia-Yi Li - 'Prion-like pathology propagation in Parkinson’s disease: the present standing'

Professor Jia-Yi Li

Professor Li received his medical degree in China in 1982, and his PhD in neurobiology at Gothenburg University in 1995. After completing postdoctoral training, he accepted a position as associate professor at Wallenberg Neuroscience Center, Lund University in 2001. Since then he has focused on... Read more

Professor Li received his medical degree in China in 1982, and his PhD in neurobiology at Gothenburg University in 1995. After completing postdoctoral training, he accepted a position as associate professor at Wallenberg Neuroscience Center, Lund University in 2001. Since then he has focused on studying pathogenetic mechanisms of neurodegenerative diseases, including Parkinson’s and Huntington’s diseases. He presently holds a permanent faculty position as a professor in neuroscience at Lund University and is the group leader of the Neural Plasticity and Repair Unit. His research group focuses on studying neuronal dysfunction, including synaptopathy and axon degeneration, neuroinflammation and misfolded protein propagation between cells in neurodegeneration, especially with modern imaging technologies. In addition, his group is also interested in seeking for optimal protocols to improve functional integration between transplanted neurons and the host in models of Parkinson disease.

Audience: Members of the University only

Organisers: Melanie Witt

Wed 22 Jun 2016 from 13:00 to 14:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Novel microscopy approaches for label-free sub-diffraction imaging

Dr Kseniya Korobchevskaya

Dr. Kseniya Korobchevskaya has obtained her PhD in the ultrafast spectroscopy laboratory at the Italian Institute of Technology (IIT). Her PhD work was focused on the design and assembly of pump-probe spectroscopy setups with different configurations for mono-, two- or multicolour measurements.... Read more

Dr. Kseniya Korobchevskaya has obtained her PhD in the ultrafast spectroscopy laboratory at the Italian Institute of Technology (IIT). Her PhD work was focused on the design and assembly of pump-probe spectroscopy setups with different configurations for mono-, two- or multicolour measurements. After graduation, Kseniya continued her work as postdoctoral researcher at IIT in the Nanoscopy group where she worked on the development of label-free near IR pump-probe nanoscope. Besides, she was also closely involved in other projects related to nonlinear microscopy, such as subtraction microscopy approach for second-harmonic generation imaging of collagen fibers or two-photon spectrofluorimetric characterization of new set of red-emitting proteins. Her main research interests lie in super-resolution microscopy, nonlinear optics, and ultrafast laser spectroscopy.

Audience: Members of the University only

Organisers: Gintare Kolesnikovaite

Seminar time has changed from 1.30pm to 1pm

Thu 23 Jun 2016 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Combined Medical-Surgical Grand Round

Professor Bill Fulford, Professor Ashok Handa

"The Montgomery ruling on consent: Values and Evidence in Surgical care", Professor Bill Fulford and Professor Ashok Handa -- Chair: TBA

"The Montgomery ruling on consent: Values and Evidence in Surgical care", Professor Bill Fulford and Professor Ashok Handa -- Chair: TBA

Audience: Public

Audience: Members of the University and NHS clinical staff.

Fri 24 Jun 2016 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Understanding the cellular response to atherogenic lipid

Dr Anil Chalisey

Audience: Members of the University only

Organisers: Anne Farmer

Mon 27 Jun 2016 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, 71A, B and C, Headington OX3 7DQ

The study of anti-cancer drug resistance using genetically engineered mouse models for BRCA1/2-mutated breast cancer

Dr Sven Rottenberg

Audience: Members of the University only

Organisers: Eric O'Neill

Mon 27 Jun 2016 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Inflammasomes dysbiosis and human disease

Richard Flavell

Audience: Members of the University only

Organisers: Linda Roberts

Tue 28 Jun 2016 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

MHU Student Presentations

Juan Pablo Ruiz; Zahra Aboukhalil; Marieke Oudelaar

Audience: Members of the University only

Organisers: Liz Rose

Wed 29 Jun 2016 from 11:15 to 12:30

CPM - WTCHG Career Equality Talks

Wellcome Trust Centre for Human Genetics, Rooms A & B, Headington OX3 7BN

CPM-WTCHG Biotech Career Workshop

Dr David Ruff, Dr Jon Sherlock, Dr Chris Spencer, Dr Alice Barkell

To inform young scientists about potential routes to becoming independent researchers and the variety of career options available. This workshop will focus on biotech careers. Speakers will briefly share the challenges and the rewards they have experienced in navigating their career paths, followed by Q & A.

To inform young scientists about potential routes to becoming independent researchers and the variety of career options available. This workshop will focus on biotech careers. Speakers will briefly share the challenges and the rewards they have experienced in navigating their career paths, followed by Q & A.

Booking Required

Audience: Members of the University only

Organisers: Susan Wilson

To attend, please email Donna: brcpa@well.ox.ac.uk for catering purposes.

Wed 29 Jun 2016 from 13:30 to 14:30

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Development of the AGM region in the chick embryo

Dr Tom Schultheiss

Audience: Members of the University only

Organisers: Liz Rose

Thu 30 Jun 2016 from 10:30 to 11:30

Nuffield Department of Primary Care Health Sciences - Department research seminars

St Luke's Chapel, Woodstock Road OX2 6GG

Symbolic violence and street-based injecting drug use

Dr Stephen Parkin

Stephen Parkin- HERG Symbolic violence and street-based injecting drug use: the control and contestation of public spaces in UK settings. This paper focuses upon Bourdieu’s theory of symbolic violence (and associated concepts of ‘tacit control’ and ‘misrecognition’) in the context of... Read more

Stephen Parkin- HERG Symbolic violence and street-based injecting drug use: the control and contestation of public spaces in UK settings. This paper focuses upon Bourdieu’s theory of symbolic violence (and associated concepts of ‘tacit control’ and ‘misrecognition’) in the context of street-based injecting drug use. More accurately, this paper provides an empirical demonstration of ‘the imposition of a cultural arbitrary by an arbitrary power’ (Bourdieu 1977, 19) in which subjective and randomised decisions by structural forces seek to control and constrain vulnerable people in spaces temporarily appropriated for injecting illicit substances. For example, symbolic violence is interpreted in the displacement of street-based injecting sites; the installation of blue lights in public toilets and within the views of people who manage public spaces affected by injecting drug use. In addition, these assorted responses are widely accepted by people who inject drugs (PWID) and become complicit in the tacit control of public space. However, symbolic violence also influences the emergence of ‘geographies of resistance’ in which PWID construct alternative injecting spaces in more marginal street-based locations. This paper is based upon findings obtained from extensive ethnographic work conducted in 4 cities during 2006-2011. The theoretical model is demonstrated with visual data obtained from visits to street-based injecting sites. The contemporary relevance and applied value of Bourdieu’s theory of symbolic violence is presented from a perspective that prioritises ‘harm reduction’ intervention and the way in which such tacit control perpetuates drug-related harm and drug-related death. Accordingly, the paper concludes with the view that symbolic violence precedes ‘micro-spatial structural violence’.

Booking Recommended

Audience: Members of the University only

Organisers: Dr Jenny Hirst

Thu 30 Jun 2016 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, TDI, Basement seminar room. (Note: not the ORCRB), Headington OX3 7FZ

Insights from methylome analysis

Dr Stephan Beck

Professor Beck’s laboratory has broad interests in the genomics and epigenomics of phenotypic plasticity in health and disease. In addition to genetic variations, they study epigenetic variations such as DNA methylation, histone modifications and microRNAs and how they modulate genome function.... Read more

Professor Beck’s laboratory has broad interests in the genomics and epigenomics of phenotypic plasticity in health and disease. In addition to genetic variations, they study epigenetic variations such as DNA methylation, histone modifications and microRNAs and how they modulate genome function. Central to their research is the development of systems approaches for integration of multi-dimensional data and their application to epigenome-wide association studies (EWAS) in cancer and other common diseases to advance translational, regenerative and personalized medicine. https://www.ucl.ac.uk/cancer/research/department-cancer-biology/medical-genomics-group

Audience: Members of the University only

Organisers: Christina Woodward