Other Seminars

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Wed 5 Sep 2018 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

“Disentangling the interconnected roles between DNA repair, NAD+, and mitophagy in ageing and neurodegeneration”

Dr. Evandro F. Fang

Dr. Evandro F. Fang is investigating the molecular mechanisms of one of the most fundamental and fascinating topics in current biology: human aging. After finished his Ph.D training in Biochemistry at the Chinese University of Hong Kong in 2012, he started a 5-year postdoctoral fellowship at the... Read more

Dr. Evandro F. Fang is investigating the molecular mechanisms of one of the most fundamental and fascinating topics in current biology: human aging. After finished his Ph.D training in Biochemistry at the Chinese University of Hong Kong in 2012, he started a 5-year postdoctoral fellowship at the National Institute on Aging USA with Dr. Vilhelm Bohr, focusing on the roles of the “human power house” mitochondria in human aging and age-related diseases, especially the role of DNA damage in neurodegeneration. In September 2017, he established his independent laboratory at the University of Oslo, Norway. His laboratory is focused on the molecular mechanisms of how cells clear their damaged and aged mitochondria, a process called “mitophagy”, as well as the roles of mitophagy in Alzheimer’s disease. He is fascinated with and actively engaged in moving his laboratory findings to translational applications, with the overarching goal to establish novel and safe biological approaches to promote longer and healthier human lives. He has published over 55 papers in peer-reviewed journals with an H index of 23. He has received several awards including The NIH Fellows Award for Research Excellence 2014, 2015, and an awardee of the prestigious Butler-Williams Scholar on Aging 2016 (USA), an FRIMEDBIO Young Research Talent 2017(Norway), and a finalist of the 2017 ERC Starting grant.

Audience: Members of the University only

Organisers: Zameel Cader

Thu 6 Sep 2018 from 10:30 to 11:30

Nuffield Department of Primary Care Health Sciences - Department research seminars

Gibson Building, Room 3, Woodstock Road OX2 6HE

PPI - Learning from colleagues

Anne-Marie Boylan

Audience: Members of the University only

Organisers: Dr Jenny Hirst

Mon 10 Sep 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

The bone: stromal cell interface in arthritis

Dr Amy Naylor

The link between stromal cells that control inflammation and tissue damage remains unclear. To this end we have endeavoured to identify stromal cell markers that are upregulated in rheumatoid arthritis and then assess their function. This seminar will discuss one such marker, CD248/Endosialin, and... Read more

The link between stromal cells that control inflammation and tissue damage remains unclear. To this end we have endeavoured to identify stromal cell markers that are upregulated in rheumatoid arthritis and then assess their function. This seminar will discuss one such marker, CD248/Endosialin, and our finding that it acts as a negative regulator of bone formation under resting conditions. We have recently identified a novel, endothelial-specific complex (Multimerin-CLEC14A) for CD248 and demonstrated that this complex is required for sprouting angiogenesis. Given that the vasculature plays a crucial role in controlling osteoblast trafficking and maturation we are now exploring the implications of manipulating this pathway during synovial inflammation and bone damage.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Tue 11 Sep 2018 from 08:30 to 18:30

Experimental Medicine TGU Seminars

Examination Schools, University Examination Schools, Oxford, 75-81 High Street OX1 4BG

Oxford IBD Masterclass

Booking Required

Audience: Public

Organisers: Professor Simon Travis

Tue 11 Sep 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Richard Doll Lecture Theatre , Old Road Campus OX3 7LF

NPEU Research Seminar - SIFT: The Speed of Increasing milk Feeds Trial

Oliver Hewer

Audience: Members of the University only

Organisers: Graham Bagley

Tue 11 Sep 2018 from 13:00 to 14:00

Population Health Seminars

NPEU Seminar - SIFT: The Speed of Increasing milk Feeds Trial

Oliver Hewer

Audience: Members of the University only

Organisers: Graham Bagley

Wed 12 Sep 2018 from 08:30 to 13:00

Experimental Medicine TGU Seminars

Examination Schools, Examination Schools 75-81 High Street OX1 4BG, 75-81 High Street OX1 4BG

Oxford IBD Masterclass

Booking Required

Audience: Public

Organisers: Professor Simon Travis

Thu 13 Sep 2018 from 16:30 to 18:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, George Pickering Education Centre, Level 3 Academic Centre, Room 2B, Headington OX3 9DU

Optimising Biologic treatments in IBD - Treat to Target

Dr Alessandro Armuzzi

Audience: Members of the University only

Organisers: Professor Holm Uhlig

Fri 14 Sep 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Simon Group

Audience: Members of the University only

Organisers: Anne Farmer

Mon 17 Sep 2018 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

Title TBC

Sabine Tejpar

Audience: Members of the University only

Mon 17 Sep 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Neuronal Regulation of Innate Lymphocytes

Dr Henrique Veiga-Ferndandes

Innate lymphoid cells (ILC) are the most recently defined cell family to be included to the increasingly complex atlas of the immune system. ILC have a lymphoid morphology, lack rearranged antigen receptors and are abundantly present at mucosal surfaces. The combined expression of lineage-specific... Read more

Innate lymphoid cells (ILC) are the most recently defined cell family to be included to the increasingly complex atlas of the immune system. ILC have a lymphoid morphology, lack rearranged antigen receptors and are abundantly present at mucosal surfaces. The combined expression of lineage-specific transcription factors with discrete cytokine profiles led to the identification of distinct ILC subsets. ILC development and function have been widely perceived to be programmed. However, emerging evidence indicates that ILC are also controlled by complex environmental signals. Here, we will discuss how ILC perceive, integrate and respond to their environment, notably to nutritional and neuronal cues. ---- Henrique Veiga-Fernandes studied Veterinary Medicine at Universidade de Lisboa, Portugal and at Università degli Studi di Milano, Italy. In 2002, he obtained a PhD in Immunology from Université René Descartes, Paris, France, before moving to the National Institute for Medical Research, London, UK, as a postdoc. In 2009, he returned to Portugal to set up his independent research group at Instituto de Medicina Molecular, where he became member of the direction team in 2014. In 2016, Henrique Veiga-Fernandes joined the Champalimaud Center for the Unknown, Portugal, where he is currently a Senior Group Leader. Henrique Veiga-Fernandes was elected a member of the European Molecular Biology Organisation (EMBO) in 2015, and he was made Commander of the Order of Sant’Iago da Espada by Portugal in the same year. He secured several European Research Council (ERC) awards (2007, 2013, 2015 and 2017) and has previously won the Pfizer Prize for basic Science (2014 and 2016), the senior research award from the Crohn’s and Colitis Foundation of America, USA (2014), the Innovator and Breakthrough Awards from the Kenneth Rainin Foundation, USA (2013 and 2014), the National Blood Foundation Scholar, USA (2012), and he integrated the EMBO Young Investigator Programme in 2008.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Tue 18 Sep 2018 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Title TBC

Dr Andrew Bassett

Audience: Members of the University only

Organisers: Liz Rose

Tue 18 Sep 2018 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Library, Sherrington Library, 2nd floor, off Parks Road OX1 3PT

Behaviour and synaptic plasticity in a model of early Parkinson's: the role of alpha-synuclei

Dr Barbara Picconi

The Neurophysiology group, under the supervision of Dr. Picconi, has been studying the various pharmacological, molecular and cellular aspects of neurodegenerative disorders through a multidisciplinary approach. In collaboration with the Laboratory of Pharmacological Sciences of the University of... Read more

The Neurophysiology group, under the supervision of Dr. Picconi, has been studying the various pharmacological, molecular and cellular aspects of neurodegenerative disorders through a multidisciplinary approach. In collaboration with the Laboratory of Pharmacological Sciences of the University of Milan (Prof Gardoni), she has characterized the role of alterations in the synaptic localization of NMDA receptors associated to altered synaptic plasticity in animal models of PD. Using cell-permeable TAT peptides, both in vitro and in vivo, it was possible to modulate the GluN2A and GluN2B subunits in synaptic sites and restore the correct synaptic plasticity in MP models. These studies have shown that TAT cell-permeable peptides by modulating the localization of the GluN2A subunit in synaptic sites lead to a significant decrease in L-DOPA dyskinesias. Recently, electrophysiological and behavioral studies in parkinsonian animals have also been performed in hippocampal cognitive areas such as CA1 and dentate gyrus (DG).

Audience: Members of the University only

Organisers: Melanie Witt

Wed 19 Sep 2018 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Professor Miles Carroll

Audience: Members of the University only

Organisers: Anne Farmer

Thu 20 Sep 2018 from 11:00 to 11:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Ethox and WEH Seminar: What gives them the right? Legal privilege and waivers of consent for research

Jon Merz

Waivers of informed consent for research participation are permitted in the United States under the Common Rule, the Health Insurance Portability and Accountability Act regulations, and the FDA's Exception from Informed Consent (EFIC) rule for emergency research. We assess the novel question... Read more

Waivers of informed consent for research participation are permitted in the United States under the Common Rule, the Health Insurance Portability and Accountability Act regulations, and the FDA's Exception from Informed Consent (EFIC) rule for emergency research. We assess the novel question regarding what legal right researchers have to carry out research procedures on or about another person, be it experimental medical intervention, psychological or social manipulation, or invasion of privacy, without the permission of their subjects. Our analysis frames waivers of consent as a species of presumed consent, and we address the underlying empirical question of whether it is reasonable to believe that subjects from whom no consent is sought would in fact agree, if asked. A scoping review of what is known about participation and refusal rates in US-based research suggests that a large minority, on average, do not agree to take part in research. Refusal rates vary widely. This suggests that, while researchers may assert the social utility of their studies are high enough to justify waivers, there is reason to suspect that many who would be enrolled under a waiver of consent would not want to be enrolled. We conclude that waivers should be rare, and that IRBs and researchers must explicitly address study acceptability in the community at large and the target population of their proposed research.

Booking Required

Audience: Members of the University only

Organisers: Christa Henrichs

Thu 20 Sep 2018 from 14:30 to 15:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, John Radcliffe Main Building, Lecture Room 1, Headington OX3 9DU

TBC

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Fri 21 Sep 2018 from 09:15 to 10:15

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Professor Mitch Kronenberg

Audience: Members of the University only

Organisers: Anne Farmer

Fri 21 Sep 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Professor Mitch Kronenberg

Audience: Members of the University only

Organisers: Anne Farmer

Mon 24 Sep 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

TNF signalling in T cells - RIPping yarns of new survival pathways

Prof Benedict Seddon

The role that NF-kB signalling plays in the development and function of T cells has been much studied, but remains poorly understood. Our work reveals that the T cell receptor is not the dominant receptor triggering NF-kB signalling during development of T cells, contrary to accepted dogma, but is... Read more

The role that NF-kB signalling plays in the development and function of T cells has been much studied, but remains poorly understood. Our work reveals that the T cell receptor is not the dominant receptor triggering NF-kB signalling during development of T cells, contrary to accepted dogma, but is rather TNF. We also reveal that TNF regulates survival and development of T cells by both NF-kB dependent and independent mechanisms and identify a new survival pathway in T cells, dependent on RIPK1. ---- I had the good fortune to undertake a PhD with Prof Don Mason at the former Medical Research Council's Cellular Immunology Unit, at the Sir William Dunn School of Pathology in Oxford University. We studied the role and mechanisms of regulatory T cells in the control of autoimmunity in rats. I then moved to the MRCs National Institute for Medical Research where I worked first as a post-doc with Dr Rose Zamoyska in the Division of Molecular Immunology, and then started my independent research group as a Programme Leader in the Division of Immune Cell Biology. 10 years at NIMR allowed me to establish a research programme investigating the mechanisms of T cell homeostasis, generating novel genetic models of TCR and cytokine signalling, employing mathematical approaches to gain systems level understanding and identifying novel roles for inflammatory signalling for T cell maturation. In 2013, I relocated the lab to the Institute of Immunity and Transplantation at the Royal Free Hospital Campus of University College London, where I am investigating the role of TNFSFR signalling and NF-kappaB transcription factors in the maturation and function of T cells in health and disease.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Fri 28 Sep 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Prof David Jackson

Audience: Members of the University only

Organisers: Anne Farmer

Fri 28 Sep 2018 from 13:00 to 14:00

NDM Seminar Series

Henry Wellcome Building of Cellular and Molecular Physiology, Seminar Rooms A & B, Roosevelt Drive OX3 7BN

NDM Seminar Series: Tropical Medicine

Professor Nick Day, Professor Phaik Yeong Cheah

Audience: Members of the University only

Organisers: Kathryn Smith