Defining RORγt-dependent transcriptional networks in human Th17 and MAIT cells

Project Overview

This project aims to understand how subsets of human white cells are controlled and how we can intervene to affect their function using novel small molecules. We are focusing on cytokine IL-17 producing cells including Th17 and a recently identified group of T lymphocytes called Mucosal Associated Invariant T cells (MAIT cells) which are both an important subset of human T cells and disease-related. 

Training Opportunities

The studentship programme will be conducted at the Nuffield Department of Medicine Experimental Medicine Division, University of Oxford. This department possesses excellent scientific facilities as well as clinical capacities for pathogenesis research especially in the field of autoimmune diseases. The researchers in the department cover different areas of medical science. Therefore, not only the members in the supervisor's group but also other members in the department can provide in-depth specialist training in advanced skills and methodologies to the student. The department offers PhD students once a week modern technology training courses and at least twice a week scientific seminars, which will broaden the knowledge of the student.


Immunology & Infectious Disease


Project reference number: 710

Funding and admissions information


Name Department Institution Country Email
Professor Paul Klenerman Experimental Medicine Division Oxford University, Peter Medawar Building GBR
Professor Luzheng Xue Experimental Medicine Division Oxford University, John Radcliffe Hospital GBR

There are no publications listed for this DPhil project.