Defining the role of cytotoxic CD4+ T cells in infection and inflammation

Project Overview

Cytotoxic CD4+ T cells are a relatively rare subset in healthy blood but can be abundant in disease. Their role is not well understood and their overlap with other functional CD4 T cell subsets in humans has not been well defined. We have new data which points to an important role of these cells in HIV and also in the gut. This project aims to

1. Define the functional heterogeneity of this subset in blood

2. Address their role in chronic viral infection - especially HIV

3. Analyse their functions in tissue, especially in the gut

Training Opportunities

Cellular immunology


Chip Cytometry

Gene expression/genomics/bioinformatics

Human immunology


Immunology & Infectious Disease and Genetics & Genomics


Project reference number: 950

Funding and admissions information


Name Department Institution Country Email
Professor Paul Klenerman Experimental Medicine Division Oxford University, Peter Medawar Building GBR

There are no publications listed for this DPhil project.