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Principal areas of research Biography Research Currently his group is involved in correlating vaccine induced protection with cell mediated immune responses to FMDV and developing viral vectored based FMD vaccines to elicit better cell mediated and mucosal immunity. These viral vectors (Sendai virus, Adenovirus and Modified Vaccinia Ankara virus) expressing FMD capsids and selected non-structural proteins along with interferons are aimed as intranasal as well as parenteral vaccines to raise specific humoral and local mucosal and cell mediated immunity on the surface of the oro-nasal mucosa, to prevent the entry of FMD virus by its usual route. Key Publications Parida S, Fleming L, Oh Y,Mahapatra M, Hamblin P, Gloster J and Paton DJ (2008). Emergency vaccination of sheep against foot-and-mouth disease: significance and detection of subsequent sub-clinical infection. Vaccine 26, 3469-3479. Parida S, Mahapatra M, Saikumar, Das S, Baron M, Anderson J and Barrett T (2007). Rescue of chimeric rinderpest virus with the nucleocapsid protein derived from Peste des Petits Ruminants (PPR) virus: Use as a marker vaccine. Journal of General Virology, 88:7, 2019-2027. Mahapatra M, Parida S, Baron M and Barrett T (2006). PPRV matrix (M) and glycoproteins (F/H) function better as a homologous complex: Development of a marker vaccine for PPRV. Journal of General Virology, 87(7): 2021-2029. Parida S, Oh Y, Reid SM, Cox SJ, Statham RJ, Mahapatra M, Anderson J, Barnett PV, Charleston B, Paton, DJ (2006). Interferon-γ production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV. Vaccine 24, 964-9. Parida S, Anderson J, Cox SJ, Barnett PV, Paton DJ (2006). Secretory IgA as an indicator of oro-pharyngeal foot-and-mouth disease virus replication and as a tool for post vaccination surveillance. Vaccine 24, 1107-1116 |
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