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Investigators

Dr Satya Parida
Tel: +44 (0) 1483 231020 or 231112
E-mail: satya.parida@bbsrc.ac.uk
Address: Institute for Animal Health, Pirbright Laboratory
Pirbright, Surrey GU24 0NF
Website: http://www.iah.ac.uk/research/FMDVDG/FMDVDG1.shtml

Principal areas of research
FMD Vaccines, Viral vectored based vaccine development, Immunological evaluations of conventional and new generation FMD vaccines.

Biography
Satya Parida was trained in Veterinary Medicine at OUAT, India, qualifying in 1987. He undertook masters in Veterinary Anatomy, Histology and Embryology at the same University. Further he undertook a D Phil in Madras Veterinary College, TANUVAS, India. Satya taught UG and PG veterinary students for 10 years in India. In 2000 he was awarded a Wellcome Trust Travelling Research fellowship to work with Prof. Tom Barrett in the Molecular Biology Division at the Institute for Animal Health, UK. Satya worked on Morbillivirus (Rinderpest and PPR) morphogenesis by application of reverse genetics. He joined as a senior scientist in FMD vaccine research during 2003 and was later promoted to Head of the FMD Vaccine Differentiation Group in the year 2007. In the same year, Satya was appointed as an adjunct professor in the School of Veterinary and Biomedical Sciences, Murdoch University, Australia.

Research
The principal research interest of Dr Parida is the development of vaccines which induce strong and protective humoral and cell-mediated immune responses. This includes work on development of genetically marked vaccines for Rinderpest, PPR, FMD and their companion tests.

Currently his group is involved in correlating vaccine induced protection with cell mediated immune responses to FMDV and developing viral vectored based FMD vaccines to elicit better cell mediated and mucosal immunity. These viral vectors (Sendai virus, Adenovirus and Modified Vaccinia Ankara virus) expressing FMD capsids and selected non-structural proteins along with interferons are aimed as intranasal as well as parenteral vaccines to raise specific humoral and local mucosal and cell mediated immunity on the surface of the oro-nasal mucosa, to prevent the entry of FMD virus by its usual route.

Key Publications
Parida S (2009). Vaccination against foot-and-mouth disease virus: strategies and effectiveness (Review). “Expert Review Vaccine”, 8 (3), 347-365.

Parida S, Fleming L, Oh Y,Mahapatra M, Hamblin P, Gloster J and Paton DJ (2008). Emergency vaccination of sheep against foot-and-mouth disease: significance and detection of subsequent sub-clinical infection. Vaccine 26, 3469-3479.

Parida S, Mahapatra M, Saikumar, Das S, Baron M, Anderson J and Barrett T (2007). Rescue of chimeric rinderpest virus with the nucleocapsid protein derived from Peste des Petits Ruminants (PPR) virus: Use as a marker vaccine. Journal of General Virology, 88:7, 2019-2027.

Mahapatra M, Parida S,  Baron M and Barrett T (2006). PPRV matrix (M) and glycoproteins (F/H) function better as a homologous complex: Development of a marker vaccine for PPRV. Journal of General Virology, 87(7): 2021-2029.

Parida S, Oh Y, Reid SM, Cox SJ, Statham RJ, Mahapatra M, Anderson J, Barnett PV, Charleston B, Paton, DJ (2006). Interferon-γ production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV. Vaccine 24, 964-9.

Parida S, Anderson J, Cox SJ, Barnett PV, Paton DJ (2006). Secretory IgA as an indicator of oro-pharyngeal foot-and-mouth disease virus replication and as a tool for post vaccination surveillance. Vaccine 24, 1107-1116

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