The malaria parasite is a shape-shifter, changing its surface coat to escape destruction by the human body. This depends upon a malaria protein called RH5 binding to a human protein called basigin on the surface of red blood cells. Unlike the other variable malaria surface proteins, RH5 does not vary, making it more easily recognised and destroyed. Jenner Investigators Sumi Biswas and Simon Draper have immunised human volunteers with RH5. Antibodies isolated from these volunteers prevent the parasite from invading red blood cells. At the RS Summer Science Exhibition they will show the public how it works, using games to detect the unchanging elements in a shape-shifting parasite, 3D models demonstrating of RH5 binding to basigin and antibodies and interactive maps to see the impact of vaccines on global health.
Nucleic acids are one of the most fundamental units of biological research. The genes coded for in DNA or RNA are integral to many research projects. Many bench methods exist for extraction of nucleic acids, but all are labour intensive and can be technically demanding. New automated solutions allow for high quality extraction of DNA or RNA, with the ability to process up to 96 samples at a time and minimal hands on time. The Jenner Institute have now launched a new Small Research Facility with the Qiagen QiaSymphony SP and Agilent Tapestation 2200 for the use of Jenner Investigators and other Oxford University researchers and external collaborators.
Malaria Vaccines: Recent Advances and New Horizons. Cell Host Microbe, 24 (1), pp. 43-56. Article
Tailoring a P. vivax vaccine to enhance efficacy through a combination of a CSP Virus-Like Particle Rv21 and TRAP viral vectors. Infect Immun. Article
Clinical trials are an essential part of vaccine development, and our volunteers play a critical role in our studies.
If you would like to find out more about paid clinical trials, and what is involved in participating, please go to our Recruiting Trials page to see which trials are currently recruiting.