Dr Teresa Lambe
| Address: | The Jenner Institute, Old Road Campus Research Building |
| Tel: | +44(0)1865 617637 |
| Email: | |
| Website: | Human Influenza Vaccine Programme |
Principal areas of research Influenza therapeutic vaccines, immune memory |
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Research
Dr. Lambe’s research interest lies in the development of efficacious influenza vaccines. Previous works, delineating the establishment and maintenance of adaptive immune memory, have been rationally applied to augment vaccine development. The deployment of such a vaccine, which induces cross-protective immune responses, will alleviate the disease burden associated with annual epidemics and occasional pandemics.
Key Publications
Berthoud, T. K., Hamill, M., Lillie, P. J., Hwenda, L., Collins, K. A., Ewer, K. J., Milicic, A.et al., Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011. 52: 1-7.
Randall, K. L.*, Lambe, T*., Johnson, A., Treanor, B., Kucharska, E., Domaschenz, H., Whittle, B.et al., Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol 2009. 10: 1283-1291.*First authors
Randall, K. L., Lambe, T., Goodnow, C. C. and Cornall, R. J., The essential role of DOCK8 in humoral immunity. Disease markers 2010. 29: 141-150.
Lambe, T., Simpson, R. J., Dawson, S., Bouriez-Jones, T., Crockford, T. L., Lepherd, M., Latunde-Dada, G. O.et al., Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. Blood 2008.
Lambe, T., Leung, J. C., Bouriez-Jones, T., Silver, K., Makinen, K., Crockford, T. L., Ferry, H.et al., CD4 T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas-Fas ligand interactions. J Immunol 2006. 177: 3055-3062.
