Dr David Wyllie

Dr_David_Wyllie
Address: The Jenner Institute, Old Road Campus Research Building
Roosevelt Drive, Oxford, OX3 7DQ
Tel: +44 (0)1865 617627
Email: david.wyllie@ndm.ox.ac.uk
Principal areas of research: Staphylococcus aureus, vectored vaccines

Research

After working in hospital medicine, I studied innate recognition of bacteria as part of my PhD. Having specialised in Infectious Diseases & Microbiology, I worked on modifying innate immune signalling in order to enhance vectored vaccine design as part of the on the Gates Grant Challenge project.

Developing a S. aureus vaccine:
At present I am focusing on enhancing surveillance of, and development of vaccines against, invasive bacterial disease, including S. aureus. We are working to develop a S. aureus vaccine, using protein antigens and vectored vaccine technology, supported by the National Institutes for Health Research.

Surveillance of infectious disease:
This activity, supported by the National Institutes of Health Research and the Oxford Biomedical Research Centre, concerns detection and study of microbial pathogens by surveillance of passively collected health data. This uses data from of the Infection in Oxfordshire Research Database, an anonymised data source containing data on microbiology, patient admission and other data from Oxfordshire. In the past, work has focused on MRSA, C. difficile and multi-resistant E. coli, but is now extending to a wider range of organisms and conditions. This work has links to the UK CRC Modernising Medical Microbiology Consortium.

Key Publications

Reyes-Sandoval, A., et al., CD8+ T Effector Memory Cells Protect against Liver-Stage Malaria. J Immunol, 2011. 187(3): p. 1347-57.

Finney, J.M., et al., An efficient record linkage scheme using graphical analysis for identifier error detection. BMC Med Inform Decis Mak, 2011. 11: p. 7.

Wong, S.H., et al., Comment on "CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node". J Immunol, 2010. 184(8): p. 4052-3.

Alcock, R., et al., Long-term thermostabilization of live poxviral and adenoviral vaccine vectors at supraphysiological temperatures in carbohydrate glass. Sci Transl Med, 2010. 2(19): p. 19ra12.

Larsen, K.C., et al., Expression of tak1 and tram induces synergistic pro-inflammatory signalling and adjuvants DNA vaccines. Vaccine, 2009. 27(41): p. 5589-98.