||Address:||The Henry Wellcome Building for Molecular Physiology (CCMP), Roosevelt Drive, Oxford OX3 7BN|
|Tel:||+44 (0)1865 287810|
|Principal areas of research||Dengue Fever and Dengue Hemorrhagic Fever|
Cesar Lopez-Camacho holds a PhD in Molecular Biology from the University of Manchester, UK. He has postdoctoral experience in molecular biology and fidelity of gene expression in hematopoietic lineages from UMASS Med School/UVM College of Medicine, USA. He is currently a Postdoctoral Researcher in the Neglected Tropical Diseases Programme led by Arturo Reyes-Sandoval.
Dengue Fever and Dengue Hemorrhagic Fever is caused by any of 4 serotypes of dengue virus (DENV). These viruses infect around 400 million persons each year, implying massive epidemic potential and tremendous economic burden. To avoid this, a DENV vaccine is needed. To date, there are two leading DENV vaccines that focus in the induction of neutralising antibodies. While they are currently in clinical trials, it has been shown that these vaccines against all four DENV serotypes are failing to protect against one or two serotypes and showing high variability depending on the geographic location tested.
Recently, it has been shown that cellular immune responses might be essential to induce protection against DENV. Our goal focuses in the development of viral-vectored vaccines encoding several regions of DENV; aiming to induce strong cellular immune responses (T-cell responses).
Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Nia Tatsis, Julie C. Fitzgerald, Arturo Reyes-Sandoval, Kimberly C. Harris-McCoy, Scott E. Hensley, Dongming Zhou, Shih-Wen Lin, Ang Bian, Zhi Quan Xiang, Amaya Iparraguirre, Cesar Lopez-Camacho, E. John Wherry, Hildegund C. J. Ertl, Blood. 2007 September 15; 110(6): 1916–1923
CBFβ and the Leukemogenic Fusion Protein CBFβ-SMMHC Associate with Mitotic Chromosomes to Epigenetically Regulate Ribosomal Gene Expression, Cesar Lopez-Camacho, Andre J. van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein, J Cell Biochem. 2014 December; 115(12): 2155–2164.
Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription. Cesar Lopez-Camacho, Wensheng Deng, Jen-Yang Tang, Daniel Mendoza-Villanueva, Apolinar Maya-Mendoza, Dean A. Jackson, Paul Shore, Proc Natl Acad Sci U S A. 2012 January 31; 109(5): 1524–1529.
Core Binding Factor β (CBFβ) is Retained in the Midbody During Cytokinesis. Cesar Lopez-Camacho, Andre J. van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein, J Cell Physiol. 2014 October; 229(10): 1466–1474, J Cell Physiol. 2014 October; 229(10): 1466–1474.