Dr Arturo Reyes
The Jenner Institute, Old Road Campus Research Building
+44 (0)1865 617623
Principal areas of research
Chimpanzee adenovirus, MVA, Plasmodium vivax malaria vaccines, dengue vaccines.
The main focus of my research at present is the study of the quality, phenotype and functionality of T cells, following immunisation with recombinant adenoviral and MVA vectors, in order to understand how these variables contribute to protection against pre-erythrocytic malaria. Such studies have been useful in determining new correlates of protection and in optimising novel vaccination regimes based on viral vectors for use in humans. The techniques and tools that I commonly use to address these scientific questions are multi-parameter flow cytometry, cell sorting by FACS, ELISpot, gene expression microarrays and cell transfer to recipient hosts.
My previous findings on P. falciparum are currently being used to create novel T-cell inducing vaccines where recombinant viral vectors are will be applied to broaden our repertoire of vaccines and include diseases such as P. vivax malaria and Dengue fever.
Reyes-Sandoval, A; Wyllie, D.H; Bauza, K; Milicic, A; Forbes, E.K; Rollier, C.S. and A.V.S. Hill. CD8+ T Effector Memory Cells protect against Liver-Stage Malaria. Journal of Immunology. doi:10.4049/jimmunol.1100302.
Rollier, C.S*; Reyes-Sandoval, A*; Cottingham, M.G; Ewer, K and A.V.S. Hill. Viral vectors as vaccine platforms: deployment in sight. Curr. Opin. Immunol. 2011. doi:10.1016/j.coi.2011.03.006.
Reyes-Sandoval A, Berthoud T, Alder N, Siani L, Gilbert SC, Nicosia A, Colloca S, Cortese R, Hill AV. Prime-boost immunization with adenoviral and modified vaccinia virus ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses. Infection and Immunity. 78(1):145-53. 2010.
Reyes-Sandoval A, Pearson FE, Todryk S, Ewer K. Potency assays for novel T-cell-inducing vaccines against malaria. Current Opinion in Molecular Therapy. 11(1):72-80. 2009.
Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, Bahjat KS, Lauer P, Reyes-Sandoval A, Hutchings CL, Moore AC, Gilbert SC, Hill AV, Bartholomay LC, Harty JT. Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. PNAS. U S A. 16;105(37):14017-22. 2008.