Current Vacancies 

Clinical Research Fellow – Transmission-stage and Blood-stage Malaria Programmes

Applications to be received by 12pm on Wednesday 30th of August 2017

Grade E64: £31,614 - £50,669 p.a.

We are seeking to appoint a Clinical Research Fellow to take an active role in the design and execution of clinical trials of investigational vaccines against malaria within the Transmission-Blocking and Blood-stage Malaria Vaccine Groups.

You will be responsible for clinical input into the trial design and execution, working closely with the clinical trials team, developing study protocols, ethical applications, advertising and recruitment, data management and analysis as well as screening and vaccination of volunteers. You will be highly organised and motivated.

You will have completed your Foundation Year 1 and 2 training and you will be fully GMC registered and permitted to practice medicine in the UK. You may have commenced or completed Core Medical Training or medical specialty equivalent. Holding a MRCP or MRCS would be an advantage.

You will have excellent communication skills, immaculate attention to detail, and good organisation and time management skills. You will have excellent interpersonal skills, including the ability to be comfortable and confident interacting with subjects and patients in a research study, including clinical research co-ordinators and other team members, laboratory and administrative staff, monitors, industry collaborators, clinical trial auditors and the broader research community. You should also be confident utilising IT and databases.

Previous laboratory and clinical trial experience, including ethics, GCP and documentation would be beneficial. Knowledge of immunology would be an advantage.

This post will provide invaluable experience for you if you are considering taking time out of clinical medicine to study for a higher degree. We are also offering you an excellent base from which you could apply for Training Fellowship funding.

The role requires some flexibility of working hours due to the nature of clinical trials.

Informal enquiries about this post can be addressed to: sumi.biswas@ndm.ox.ac.uk.

To apply, please complete an online application form and attach a copy of your CV and supporting statement.

Only applications received before 12.00 noon on Wednesday 30 August 2017 will be considered. Interviews are likely to be held week commencing 11 September 2017. Actual date will be confirmed.

Contact: HR Officer - Recruitment (01865 617971)

To apply and view a Job Description

Postdoctoral Research Scientist - Monoclonal Antibody Production and Testing

Applications to be received by 12pm on Monday 7th of August 2017

Grade 7: £31,076 - £38,183 p.a.

We require a Postdoctoral Research Scientist to perform work related to monoclonal antibody (mAb) generation, characterisation and functional testing. As the Postdoctoral Research Scientist, you will support across a number of on-going immunology projects where the generation or testing of mAbs is required. We are particularly looking for someone with prior experience of mAb generation, either by hybridoma methods or robot technologies, and subsequent mAb characterisation, in particular by surface plasmon resonance/Biacore. Previous experience of mAb engineering or cloning would be highly desirable.

You will be highly organised, with proven experience in a laboratory environment. You will have good interpersonal skills and be able to interact productively and accurately with other team members. Previous laboratory experience, good communication skills and the ability to work as part of a team are essential.

You will be educated to a doctoral degree (or near completion) in a subject relevant to antibody development. Experience of surface plasmon resonance/Biacore and the ability to research complex issues and interpret, analyse, and present scientific data and write factual reports.

Informal enquiries about this post can be addressed to: simon.draper@ndm.ox.ac.uk.

Applications for this vacancy are to be made online, and as part of the application you will be required to upload a CV and covering letter.

Only applications received before 12.00 noon on 7 August 2017 will be considered.

Contact: HR Officer - Recruitment (01865 617971)

To view Job Description and apply

Postdoctoral Immunologist – Preclinical Malaria Vaccine Development

Applications to be received by 12pm on Monday 31st of July 2017

Grade 7: £31,076 - £38,183 p.a.

A Postdoctoral Immunologist with a doctoral degree (or near completion) in a subject relevant to immunology/vaccine development is required to join Professor Simon Draper’s group.

In your role as Postdoctoral Immunologist, you will need to be self-motivated, technically competent and capable of working independently in a laboratory. You will have excellent communication and interpersonal skills, and you will be able to work effectively with others. Good documentation and computer skills are essential and you should demonstrate the ability to research complex immunological issues and interpret, analyse, and present scientific data and write reports.

Previous experience of in vivo rodent immunology, molecular biology and sterile cell culture techniques including cloning and PCR are required.

The post is initially funded for 2 years. We will be applying for further funding to support longer-term continuation of this post. Alternatively, we would also be keen to hear from suitably-qualified applicants who wish to use this post to develop towards an independent research career by means of assembling an application for a postdoctoral fellowship.

Informal enquiries about this post can be addressed to: simon.draper@ndm.ox.ac.uk.

If you are interested in this role, and have the skills and experience we are looking for, please apply online.

Only applications received before 12.00 noon on 31 July 2017 will be considered.

Contact: HR Officer - Recruitment (01865 617971)

To view a Job Description and apply

Senior Vaccine Production Scientist

Applications to be received by 12pm on Monday 31st of July 2017

Grade 6: £27,629 - £32,958 p.a.

We have an exciting opportunity for a Senior Vaccine Production Scientist to join our Operations Team in the Clinical BioManufacturing Facility (CBF).

You will be manufacturing Investigational Medicinal Products (IMP) in our suite of Good Manufacturing Practice (GMP) cleanrooms supporting the Jenner Institute’s pipeline of novel vaccines for a variety of diseases, including vaccines against MERS, Zika and Chikungunya viruses. You will be responsible for ensuring that Upstream, Downstream and Fill and Finish processes are performed to the highest standards and according to pre-determined procedures and timelines under the guidance of the Operations Manager. You will oversee the work of a small team of production staff.

You will be highly organised and motivated with good interpersonal skills. Excellent communication skills and the ability to work both as part of a team and independently are essential. You will be educated to BSc degree (or equivalent) in a relevant subject with extensive relevant experience. You will be able to work in a cleanroom environment and you have been working in a regulated environment. You are experienced in mammalian cell culture, with good aseptic technique.

Strong communication, planning, and prioritising skills as well as basic computer skills are needed. You should be a team player with previous supervisory experience. A critical eye for ensuring full compliance to approved processes is expected.

Experience in working in cleanrooms according to GMP, IMP manufacture and virus handling and culture as well as biological downstream processing techniques are desirable. Willingness to participate in the out of hours on-call rota, responding to equipment and building alarms, would be ideal.

You will be required to upload a CV and Supporting Evidence Form which explains how you meet the selection criteria for the post.

Only applications received before 12.00 noon on 31 July 2017 will be considered. 

Contact: HR Officer - Recruitment (01865 617971)

To view Job Description and apply

Postdoctoral Scientist in HCV Vaccine model development

Peter Medawar Building for Pathogen Research, South Parks Road, Oxford, OX1 3SY

Grade 7: £31,076 - £38,138 per annum

We seek to appoint a Post-doctoral Scientist, with experience and interest in infectious diseases / vaccinology to develop a new vaccine model for hepatitis C virus (HCV). This will be used to evaluate the immunogenicity and efficacy of a range of novel vectors and immunisation strategies in advance of human trials.

Development of an effective preventative or prophylactic vaccine is a pressing clinical need, both in the UK and worldwide. HCV is a major cause of severe liver disease in the estimated 160 million people infected with the virus. While there is treatment available, conventional therapies based on interferon are effective in only a proportion of those treated while more recently developed antiviral therapy that directly targets the virus is expensive and its use will remain cost-limited for many years. Importantly, such treatments will not stem the spread of HCV and the large numbers of new infections recorded every year; even those who have been effectively treated remain prone to re-infection. HCV also poses a much greater medical problem worldwide where access to treatment will remain limited; HCV-related deaths worldwide exceed 350,000 per year, comparable to those AIDS, TB and malaria.

The development of HCV vaccine has been hampered by a lack of animal models with which to test different types of vaccine. It has also proven exceptionally difficult to develop vaccines that induce long-lived protective immunity - even clearance of natural HCV infection does not protect from subsequent re-infection, quite unlike the situation of poliovirus, measles and hepatitis A virus (as examples) for which effective vaccines have been developed.

The project will investigate the effectiveness of novel vaccines based on the insertion of HCV protein-coding sequences into cytomegalovirus (CMV) or adenovirus (AdV) vectors. Vaccine candidates based on these vectors will be evaluated for immunogenicity and protection from virus challenge using a novel in vitro model. Rodent hepacivirus (RHV) is closely related to HCV, infects rats and causes the same pattern of liver disease and frequency of persistence as HCV in humans. In our planned project, we will develop CMV and AdV vectors containing genes from RHV to directly evaluate whether this approach can generate protective immunity and can clear RHV infection in rats that are chronically infected with the virus. Based on previous experience with CMV/SIV vaccine candidates in macaques, we believe this strategy will also prove effective for HCV and if confirmed, could translate through very rapidly into human clinical trials.

The appointee will be based at the Peter Medawar Building for Pathogen Research in central Oxford. He/she will be supervised by Peter Simmonds (virology), Ellie Barnes (vaccines) and Paul Klenerman (immunology) and be a member of a larger team of scientists with interests in the fields of immunology, vector design and gene expression technologies. There will be close collaborative links, and sharing of expertise, with the Jenner Institute (Oxford) and Michael Jarvis (University of Plymouth, CMV vector design and construction).

Selection criteria

 Desirable selection criteria 

For further information, please contact: Prof Ellie Barnes.