Postdoctoral Scientist
Salary scale for University Staff Grade 7: (£28,983 - £35,646) per annum
We are seeking to recruit an enthusiastic, highly-motivated postdoctoral researcher with cellular immunological expertise to join a small research team studying innate immune responses in HIV infection, aiming to define the contribution they make to control of early viral replication and determine the potential for employing modulation of selected innate responses as an effector strategy in HIV vaccine development. The work is supported by the NIH and forms part of the Centre for HIV and AIDS Vaccine Immunology (CHAVI), an international research consortium aiming to identify new approaches to HIV vaccine design. The post is available immediately and will be tenable until June 30th 2012 (subject to confirmation of funding). It will be based in the Jenner building, Compton, Berkshire until January 2011, and in Oxford thereafter.
A PhD level degree in a medical/biological field and at least 2 years research experience in the field of cellular immunology are required, with expertise in multi-parameter flow cytometry being highly desirable. Good organisational, communication and team-working skills are also required. Prior experience in handling human PBMCs and working with pathogens such as HIV under containment level 3 conditions would also be advantageous. Informal enquiries should be directed to Dr Persephone Borrow (persephone.borrow@ndm.ox.ac.uk).
An application form and a job description are available from the below links or from the Personnel Office on tel: 01865 617604/644 or email: orcrb.personnel@ndm.ox.ac.uk. Please quote the reference HC-10-020-GS.
The closing date for applications is no later than 12 noon on Friday, 24th September 2010. Applications received after this deadline will not be accepted.
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Production Manager- Clinical BioManufacturing Facility
Academic-related Grade 7: Salary range (£28,983 – 35,646) p.a.
The Clinical BioManufacturing Facility is the University of Oxford’s GMP (Good Manufacturing Practice) manufacturing facility, where the basic research into vaccines can be translated into an Investigational Medicinal Product (IMP) used in first in man clinical trials.
The CBF has over 15 years experience producing biological IMPs according to GMP for early phase clinical trials. It has a Manufacturer’s Authorisation for Investigational Medicinal Products (MA (IMPs)) from the Medicines and Healthcare Products Regulatory Agency (MHRA) and is currently manufacturing adenoviral vectors for use as novel vaccines and cancer therapies
We are seeking to recruit an experienced and ‘hands- on’ cGMP Production Manager to be responsible for ensuring all quality and regulatory aspects can be met to ensure the smooth translation (working with process development team) of novel academic research Advanced Therapies into the highly regulated cleanroom manufacturing environment of the CBF.
The successful candidate will have a life science degree or equivalent with a proven track record in a similar role ideally with biopharmaceutical / biotechnological experience gained in industry. In addition they will have prior experience of regulatory inspection, internal and external audits. Excellent organizational skills, the ability to work independently and as part of a team, and an ability to communicate and develop effective working relationships with a wide range of staff at all levels, internally and externally (academic collaborators and the regulatory authorities) are all required. They must be able to work under pressure and under strictly defined regulatory and safety conditions whilst maintaining a high degree of accuracy. The applicant must have an adaptable approach to work and a willingness to tackle a variety of tasks. Good record-keeping skills are essential.
The candidate should have solid working experience in a regulated GMP environment managing and controlling clean room discipline and be confident they will be able to ensure systems and procedures used for the manufacturing of academic IMPs are both robust enough to satisfy the legal requirements yet pragmatic enough to creatively address the challenges that manufacture of novel therapies will always pose whist ensuring patient safety paramount.
An ability to work without supervision and to combine a structured and organised approach with enthusiasm will be important.
An application form and a job description are available from the below links or from the Personnel Office on Tel: 01865 617604/644 or Email: orcrb.personnel@ndm.ox.ac.uk. Please quote the reference HC-10-017-GS.
The closing date for applications is no later than 12 noon on Friday, 10th September 2010. Applications received after this deadline will not be accepted.
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Laboratory Assistant /Junior Technician
Salary scale for University Grade 3: (£17,111 - £19,743) per annum – full time at 36.5 hours or part time pro rata at 25 hours per week.
Applications are invited for a Laboratory Assistant at the Centre for Clinical Vaccinology and Tropical Medicine located on the Churchill Hospital site.
You will be part of the technical support team providing assistance to scientists ensuring that the laboratories are well stocked, maintained and operating to a high standard. You will also be required to operate autoclaves, glass washing machines and undertake simple servicing/maintenance of laboratory equipment. Ability to follow clear instructions and attention to detail is essential as the laboratories operate under a quality control system. The post holder will also be required to make up reagents and prepare items for sterilisation following a set of standard operating procedures (SOP).
The successful candidate will be highly organised, physically fit and show a keen interest in delivering a first class service. Applications will be considered from individuals who do not meet the full selection criteria but who are interested in appointment at a lower grade (Junior Technician) whilst undertaking further education/training to progress onto a technician grade.
For further information or informal enquires please contact the Business Manager (gary.strickland@ndm.ox.ac.uk).
An application form and a job description are available from the below links or from the Personnel Office on tel: 01865 617604/644 or email: orcrb.personnel@ndm.ox.ac.uk. Please quote the reference HC-10-019-GS.
The closing date for applications is no later than 12 noon on Friday, 17th September 2010. Applications received after this deadline will not be accepted.
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Technical Assistant (1 year Maternity Cover) - Clinical Biomanufacturing Facility
Salary scale for University Grade 3: (£17,111 - £19,743) per annum
The Clinical BioManufacturing Facility (CBF) is the University of Oxford’s GMP (Good Manufacturing Practice) manufacturing facility.
We are seeking to recruit a technical assistant to join this small team of staff at the CBF. We require a person to undertake basic duties in our cleanrooms and laboratories in support of our team of quality control and production scientists. This will include the following; preparation of material for production, culture of mammalian cells, maintenance of cleanroom to GMP requirements, checking equipment, ensuring materials are available for use, operating sterilising and washing equipment.
Previous experience in working in a laboratory or a clean room environment and aseptic technique would be an advantage but it is not essential. Full training will be given. You will need to have literacy, computer and numeracy skills along with good attention to detail and self motivation.
The post is based at the Clinical Biomanufacturing Facility, Churchill Hospital, Oxford (www.cbf.ox.ac.uk). Informal enquiries to Emma Bolam (Tel 01865 744845; email emma.bolam@ndm.ox.ac.uk).
An application form and a job description are available from the below links or from the Personnel Office on tel: 01865 617604/644 or email: orcrb.personnel@ndm.ox.ac.uk. Please quote the reference Please quote the reference HC-10-015-GS.
The closing date for applications is midday on Friday, 10th September 2010. Applications received after this deadline will not be accepted.
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Research Assistant – Malaria Vaccine Trials
Salary scale for University Staff Grade 6: (25,751 – £30,747) per annum
Professor Adrian Hill’s research group has developed new candidate vaccines for liver-stage and blood-stage malaria. For the last four years we have been conducting phase Ia and IIa clinical trials to evaluate the safety and immunogenicity of these vaccines in healthy volunteer subjects in the UK, including experimental malaria challenge studies to test vaccine efficacy. Parallel studies evaluating the safety and immunogenicity in malaria endemic areas (The Gambia and Kenya) are also underway. We require a research assistant to perform immunological assays to measure responses induced by such vaccines in Phase Ia and IIa vaccine trials in Oxford. Although most vaccines studied are designed and developed within the University, vaccines under development by industrial and other collaborators are also evaluated periodically.
A research assistant is required to join Professor Adrian Hill’s & Dr Simon Draper’s blood-stage malaria vaccine development group at the Jenner Institute, University of Oxford. The research programme focuses on pre-clinical and clinical testing of novel vectored blood-stage malaria vaccines. You will be part of the clinical trials team and will work on the evaluation of candidate vaccines in clinical trials.
The position involves supporting the general program of immunology within the human malaria vaccine trials. This includes general lab duties (maintaining supplies, consumables and instruments); preparing reagents; cataloguing frozen samples; and some data analysis. The successful candidate will be highly organized, with proven experience in a laboratory environment.
You will have good interpersonal skills and be able to interact productively and accurately with other team members. Previous laboratory experience, good communication skills and the ability to work as part of a team are essential. The research involves cellular immunology techniques carried out with human blood samples including ELISPOT, ELISA, and sterile cell culture (full training will be given). Experience of working to GLP would be an advantage.
The position will be based at the new Jenner Institute Laboratories, at the university’s Old Road Campus in Headington.
An application form and job description are available from the links below or from the Personnel Office on Tel: +44 (0)1865 617604/644, Email:orcrb.personnel@ndm.ox.ac.uk. Please quote the reference HC-10-016-GS.
The closing date for applications is midday on Friday, 17th September 2010. Applications received after this deadline will not be accepted.
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